Disruptive technology projects to face new challenges

BioprintedQCM, proyecto de Consolidación de la Cadena de Valor Empresarial

The main goal of the BioprintedQCM project is to carry out the industrial research processes necessary for the development of a new biochemical surface functionalization technique that allows immobilizing biorecognition probes such as aptamers, antibodies or DNA sequences on the surface of acoustic micro-resonators in a precise, controlled, fast, repeatable manner and at a reduced cost. The BioprintedQCM technique will be applied in the development of new biosensors based on HFF-QCM ARRAY devices, proprietary of the Valencian technology-based company AWSensors.

ERAGUA: Plataforma Avanzada para el Control Digital e Integral de la Calidad de Aguas Regeneradas

The ERAGUA project’s main objective is to develop an innovative digital platform for the intelligent management of the quality of reclaimed water, based on the analysis of microbiological parameters and emerging contaminants (EC). Microbiological parameters include viruses, protozoa (Cryptosporidium and Giardia), and antibiotic resistance genes (ARG). Regarding ECs, priority will be given to microplastics and substances listed in Directive 2024/3019 of the European Parliament, which are mostly pharmaceuticals, although other compounds of environmental interest are also included.

Partners:

EUROFINS IPROMA S.L.U.
SOCIEDAD DE FOMENTO AGRÍCOLA CASTELLONENSE, S.A. (FACSA)
ADVANCED WAVE SENSORS, S.L.
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, M.P. (CSIC)
UNIVERSITAT POLITÈCNICA DE VALENCIA (UPV)
AINIA

MicroQ-KINETICS: Plataforma de Microarrays HFFQCM para el Estudio de Cinéticas de Interacciones Biomoleculares en Tiempo Real

The “MicroQ-KINETICS” project aims to develop a comprehensive technological platform of acoustic biosensors based on HFFQCM (High Fundamental Frequency Quartz Crystal Microbalance) microarrays for real-time, label-free biomolecular interaction kinetics analysis, offering high sensitivity, low cost, and low sample volume. The platform, named μQ-Kinetics, will integrate high-frequency acoustic sensors (100–150 MHz) arranged in array configurations of 8 and 24 sensors fabricated on a single quartz wafer, encapsulated in a cartridge-type cell with microfluidic integration, and mechanical, electrical, and thermal connectivity. This platform will be capable of measuring kinetic parameters such as association/dissociation rates (ka, kd) and affinity constants (KD), with key applications in drug development, immunology, structural biology, and biomarker characterization.